Sam and Dean investigate a house occupied by a female ghost, but when a new family moves in things take a turn for the worse.

Three superheroes from the future travel to the past and join Clark in hopes that together they can defeat Brainiac, who has taken over Chloe's body.

Clark is attacked by the Persuader in his barn, but before he is killed a trio of superpowered aliens, called the Legion, shows up and saves him. While inhabiting Chloe's body, Brainiac informs Davis that he will soon become the creature "Doomsday" permanently, and places him in an ice cocoon for the metamorphosis. Rokk, Imra, and Garth inform Clark that today was the day he was supposed to destroy Brainiac for good, but because the only way for him to do that will be to kill Chloe. Brainiac begins sucking the knowledge from every human mind through the world's computer network when he is attacked by the Legion. Before the Legion can kill Chloe Clark intervenes and convinces them to focus their powers and pull Brainiac out of Chloe. Afterward, the Legion takes what is left of Brainiac with them back to the future to reprogram him for something positive.

Penny's criticism of Wolowitz's romantic life pushes him into depression and AWOL for a fighting robot battle the rest of guys are depending on him for.

Following Amanda's abduction in "I've Had the Time of My Life", Kyle plots to rescue her from Latnok's clutches with Jessi's assistance.

News of Peyton's condition spreads like wildfire through Tree Hill. Brooke tries to suss out Julian's intentions. Mouth and Millicent strive to keep their relationship going. Meanwhile, Peyton and Lucas babysit Jamie and his friend when Nathan and Haley spend a night out together.

In the reading of Bart's will, Chuck, Bart's brother, Jack and Lily learn that Chuck is now the CEO of Bass Industries. Chuck agrees that Jack became his guardian.

Rufus and Lily's relationship is strained as Rufus searches for details about the child he never knew he had. Noticing the strange way his father has been acting lately, Dan does some investigating and uncovers Rufus and Lily's secret, and he has to decide now what to do and who to tell the shocking revelation.