House and his team deal with a man living in constant pain. Meanwhile, Thirteen receives treatment by Foreman while taking part in his clinical trial on Huntington's Disease, and Cuddy tries to balance her hospital duties with her new baby.

Kyle fears for Amanda's life after a psychic gives him a stark warning.

Lucas and Julian have a difficult time finding the right director for their movie. Meanwhile, a present from Lucas confuses Peyton and Brooke battles with romantic complications.

Sheldon develops an algorithm to make friends.

Who will get in the Ivy League institution of their choice? The students find out who is worthy of an early admission to Yale. Serena connects with a new Shakespeare teacher, who has no clue about what is going to happen when she gives Blair the first B grade in her life. Chuck pairs up with an unlikely ally in his battle over Bass Industries. Nate and Vanessa have a romantic night at the opera.

Aided by the young Princess Rachel, Zedd allows himself to be captured to prevent Darken Rhal from acquiring the third and last Box of Orden.

Fearing that her feelings for Richard may compromise his mission to stop Rahl, Kahlan leaves Richard and Zedd to find another Confessor who can help them. Shortly after, Richard is captured by a Mord'Sith named Denna who can manipulate any form of magic directed at her; Zedd is powerless to help. Denna reveals to Richard of Rahl's plan to torture him into submission. As she tortures him, Kahlan locates Lara, a Confessor who has abused her power to gain control over an entire settlement. Upon learning from Zedd that Richard has been captured, Kahlan goes to save Richard. Lara is killed by Rahl's soldiers and the people she confessed are freed from her control. Richard and Kahlan escape from captivity after killing Denna, who is brought back to life by another Mord'Sith. When Richard tells Kahlan that he knows of her secret, she reaffirms that they must focus on their mission and cast aside their feelings for each other.

Sam and Dean investigate a house occupied by a female ghost, but when a new family moves in things take a turn for the worse.

Three superheroes from the future travel to the past and join Clark in hopes that together they can defeat Brainiac, who has taken over Chloe's body.

Clark is attacked by the Persuader in his barn, but before he is killed a trio of superpowered aliens, called the Legion, shows up and saves him. While inhabiting Chloe's body, Brainiac informs Davis that he will soon become the creature "Doomsday" permanently, and places him in an ice cocoon for the metamorphosis. Rokk, Imra, and Garth inform Clark that today was the day he was supposed to destroy Brainiac for good, but because the only way for him to do that will be to kill Chloe. Brainiac begins sucking the knowledge from every human mind through the world's computer network when he is attacked by the Legion. Before the Legion can kill Chloe Clark intervenes and convinces them to focus their powers and pull Brainiac out of Chloe. Afterward, the Legion takes what is left of Brainiac with them back to the future to reprogram him for something positive.

Penny's criticism of Wolowitz's romantic life pushes him into depression and AWOL for a fighting robot battle the rest of guys are depending on him for.

Following Amanda's abduction in "I've Had the Time of My Life", Kyle plots to rescue her from Latnok's clutches with Jessi's assistance.

News of Peyton's condition spreads like wildfire through Tree Hill. Brooke tries to suss out Julian's intentions. Mouth and Millicent strive to keep their relationship going. Meanwhile, Peyton and Lucas babysit Jamie and his friend when Nathan and Haley spend a night out together.

In the reading of Bart's will, Chuck, Bart's brother, Jack and Lily learn that Chuck is now the CEO of Bass Industries. Chuck agrees that Jack became his guardian.

Rufus and Lily's relationship is strained as Rufus searches for details about the child he never knew he had. Noticing the strange way his father has been acting lately, Dan does some investigating and uncovers Rufus and Lily's secret, and he has to decide now what to do and who to tell the shocking revelation.