House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.

After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill, and as her condition worsens, becomes unable to distinguish fact from fiction. Meanwhile, Cuddy and Wilson attend a medical conference for pharmacology and public policy. House tags along, planning to use the outing as an opportunity to push a personal agenda, but things don’t go as expected.

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